' 
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
9
Vitamin D3 may reduce brain edema
Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study.
High relevance to vitamin D3 effects
We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
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8
Vitamin D3 and glioma cell senescence
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
Direct impact on glioma treatment
We investigated the effects of 1,25-dihydroxyvitamin D3, the active form of vitamin D3, on glioma cells to understand its potential role in brain tumor treatment. Our study showed that this compound can induce cellular senescence, a state where cells stop dividing and can no longer contribute to tumor growth.
Specifically, we observed that vitamin D3 increased the levels of key senescence markers, INK4A and CDKN1A, suggesting that it effectively slows down the progression of glioma. Additionally, vitamin D3 upregulated KDM6B, a histone demethylase that plays a crucial role in promoting the expression of INK4A by altering the chemical modifications on chromatin that repress its transcription.
By knocking down KDM6B, we found that the senescence induced by vitamin D3 was reduced, indicating that KDM6B is essential for this process. Overall, our findings reveal a new mechanism by which vitamin D3 could help inhibit the growth of glioma, paving the way for future prevention and treatment strategies.
Specifically, we observed that vitamin D3 increased the levels of key senescence markers, INK4A and CDKN1A, suggesting that it effectively slows down the progression of glioma. Additionally, vitamin D3 upregulated KDM6B, a histone demethylase that plays a crucial role in promoting the expression of INK4A by altering the chemical modifications on chromatin that repress its transcription.
By knocking down KDM6B, we found that the senescence induced by vitamin D3 was reduced, indicating that KDM6B is essential for this process. Overall, our findings reveal a new mechanism by which vitamin D3 could help inhibit the growth of glioma, paving the way for future prevention and treatment strategies.
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8
Vitamin D treatment shows promise
Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.
Study highlights vitamin D efficacy
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
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Most Useful Reviews
9.5
Improved vitamin D
Finally, a high-dose vitamin D supplement at a great price. The quality is superb since it's filled with virgin olive oil. I have a severe vitamin D deficiency, so this high dosage is essential. Remember to take it with vitamin K2 for optimal absorption; vitamin D is important for modulating immunity and has anti-tumour effects. Most people are vitamin D deficient.
Read More
8.8
Relief experienced
Excellent, I've used this once a week while following the keto diet, and I have a brain tumor in the uterus. I felt a lot of relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
Vitamin D3 shows promise against glioblastoma
Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide.
Moderately relevant combination findings
We explored the potential of calcitriol, the active form of vitamin D, in treating glioblastoma, one of the most aggressive brain tumors. Our research aimed to see if vitamin D could target the stem-like cells that contribute to tumor growth and resistance to treatment.
Through a combination of lab tests, including real-time PCR and organ transplant cultures, we found that calcitriol can effectively reduce the stem-like properties of glioblastoma stem cells. Interestingly, it also worked well alongside Temozolomide, a common chemotherapy drug, helping to improve its effectiveness. In some cases, the combination completely eliminated the tumor cells we analyzed.
These promising results suggest that calcitriol could serve as an important part of treatment for certain patients with glioblastoma. However, further studies will be essential to fully understand its potential and optimize its use in clinical settings.
Through a combination of lab tests, including real-time PCR and organ transplant cultures, we found that calcitriol can effectively reduce the stem-like properties of glioblastoma stem cells. Interestingly, it also worked well alongside Temozolomide, a common chemotherapy drug, helping to improve its effectiveness. In some cases, the combination completely eliminated the tumor cells we analyzed.
These promising results suggest that calcitriol could serve as an important part of treatment for certain patients with glioblastoma. However, further studies will be essential to fully understand its potential and optimize its use in clinical settings.
Read More
9
Vitamin D3 may reduce brain edema
Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study.
High relevance to vitamin D3 effects
We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Read More
9
Vitamin D analogs inhibit glioblastoma
Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells.
Relevant to brain tumor treatment
We investigated how synthetic analogs of vitamin D, specifically tacalcitol and calcipotriol, impact the growth and movement of T98G human glioblastoma cells. This type of brain cancer is particularly aggressive and challenging to treat, making it vital to explore new therapeutic options.
Our findings revealed that both vitamin D analogs significantly decreased cell viability and reduced the rate at which these cancer cells proliferated. This was evident in our tests, where even low concentrations of the analogs, ranging from 1 nM to 10 μM, showed a notable suppression of cell growth.
We also conducted a wound-healing assay to assess the migration of T98G cells. Both tacalcitol and calcipotriol were effective in slowing down the movement of these cells compared to a control group. Interestingly, even though we saw these promising effects, the analogs did not appear to trigger apoptosis, as measured by caspase-3 and -7 activities.
Overall, our research supports the potential of vitamin D analogs as a promising avenue for the treatment of glioblastoma by significantly inhibiting both the growth and migration of cancer cells.
Our findings revealed that both vitamin D analogs significantly decreased cell viability and reduced the rate at which these cancer cells proliferated. This was evident in our tests, where even low concentrations of the analogs, ranging from 1 nM to 10 μM, showed a notable suppression of cell growth.
We also conducted a wound-healing assay to assess the migration of T98G cells. Both tacalcitol and calcipotriol were effective in slowing down the movement of these cells compared to a control group. Interestingly, even though we saw these promising effects, the analogs did not appear to trigger apoptosis, as measured by caspase-3 and -7 activities.
Overall, our research supports the potential of vitamin D analogs as a promising avenue for the treatment of glioblastoma by significantly inhibiting both the growth and migration of cancer cells.
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8
Vitamin D3 boosts glioblastoma treatment
Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform.
Potential treatment strategy explored
We developed an innovative method to tackle glioblastoma, a particularly aggressive brain tumor. Our approach involved creating a unique nanoplatform that combines vitamin D3, lipids, and neutrophil membranes to enhance the treatment's effectiveness.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Read More
8
Vitamin D's role in glioma treatment
The Immunomodulatory Effects of Vitamin D on COVID-19 Induced Glioblastoma Recurrence via the PI3K-AKT Signaling Pathway.
Study highlights complex interactions
We delved into the complex relationship between vitamin D and glioma, particularly amid the challenges COVID-19 poses for patients with this aggressive brain cancer. Through our investigation, we identified 203 genes that were commonly altered in both glioma and COVID-19 infections. Among these, we pinpointed six key genes that can influence patient outcomes, including MYBL2, RBM6, VEPH1, AHNAK2, GNG10, and DUSP14.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved vitamin D
Finally, a high-dose vitamin D supplement at a great price. The quality is superb since it's filled with virgin olive oil. I have a severe vitamin D deficiency, so this high dosage is essential. Remember to take it with vitamin K2 for optimal absorption; vitamin D is important for modulating immunity and has anti-tumour effects. Most people are vitamin D deficient.
Read More
8.8
Relief experienced
Excellent, I've used this once a week while following the keto diet, and I have a brain tumor in the uterus. I felt a lot of relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
Read More
